Dynamics of neuronal and non neuronal networks underlying memory processing (MEMORY)

Our research aims at elucidating the mechanisms underlying learning and memory processes. We are particularly interested in understanding how the brain organizes the formation and storage of enduring memories in physiological and pathological conditions. To this end, we use animal models (mice and rats) of human memory which enable to mimic specific rare diseases such as neurodevelopmental disorders (autism) or pathologies such as arterial hypertension. The originality of our correlative (brain imaging) and causal (manipulation of cerebral activity) approaches lies in integrating the neuronal and non-neuronal (e.g. the vascular network) dimensions of brain functioning. We are also exploring the impact of gravitational modifications (simulated microgravity or hypergravity) on brain functions in order to better understand the adaptive mechanisms triggered during long-duration spaceflights which may be responsible for the brain fog symptom sometimes experienced by astronauts, potentially affecting their sensory and cognitive abilities.