Sleep/Wake, Aging, Neuroimaging (SWAN)

A core objective of our research is to examine the impact of sleep/wake disturbances on daytime functioning to elucidate the etiology and pathophysiology of age-related CNS disorders. Cognitive symptoms and physiological malfunctioning are assessed in clinical studies but also in population-based cohorts. We apply advanced neuroimaging techniques using multimodal approach coupling morphological and functional MRI techniques and dailylife assessment based on connected devices for sleep/wake cycle (actigraphic watch) and cognition (EMA on smart phone). More specifically, daily life evaluations unravel the intra-individual variability of physiological and cognitive functioning; we attempt to understand its anatomical and functional bases by analysing it in relation to brain networks.