A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes in male mice.
Ignacio Fernández-Moncada, Gianluca Lavanco, Unai B. Fundazuri, Nasrin Bollmohr, Sarah Mountadem, Tommaso Dalla Tor, Pauline Hachaguer, Francisca Julio-Kalajzic, Doriane Gisquet, Roman Serrat, Luigi Bellocchio, Astrid Cannich, Bérénice Fortunato-Marsol, Yusuke Nasu, Robert E. Campbell, Filippo Drago, Carla Cannizzaro, Guillaume Ferreira, Anne-Karine Bouzier-Sore, Luc Pellerin, Juan P. Bolaños, Gilles Bonvento, L. Felipe Barros, Stephane H. R. Oliet, Aude Panatier, Giovanni Marsicano
Nat Commun. 2024-08-09
10.1038/s41467-024-51008-2

An enquiry to the role of CB1 receptors in neurodegeneration.
Ignacio Fernández-Moncada, Abel Eraso-Pichot, Tommaso Dalla Tor, Bérénice Fortunato-Marsol, Giovanni Marsicano
Neurobiology of Disease. 2023-08-01
10.1016/j.nbd.2023.106235

Type‐1 cannabinoid receptors and their ever‐expanding roles in brain energy processes
Ignacio Fernández‐Moncada, Rui S. Rodrigues, Unai B. Fundazuri, Luigi Bellocchio, Giovanni Marsicano
Journal of Neurochemistry. 2023-07-28
10.1111/jnc.15922

Metabolic Recruitment in Brain Tissue.
L.F. Barros, I. Ruminot, T. Sotelo-Hitschfeld, R. Lerchundi, I. Fernández-Moncada
Annu. Rev. Physiol.. 2023-02-10
10.1146/annurev-physiol-021422-091035

Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?
Ignacio Fernández-Moncada,Giovanni Marsicano
Essays in Biochemistry. 2023-01-16
10.1042/EBC20220089

Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis.
Joris Guyon, Ignacio Fernandez‐Moncada, Claire M Larrieu, Cyrielle L Bouchez, Antonio C Pagano Zottola, Johanna Galvis, Tiffanie Chouleur, Audrey Burban, Kevin Joseph, Vidhya M Ravi, Heidi Espedal, Gro Vatne Røsland, Boutaina Daher, Aurélien Barre, Benjamin Dartigues, Slim Karkar, Justine Rudewicz, Irati Romero‐Garmendia, Barbara Klink, Konrad Grützmann, Marie‐Alix Derieppe, Thibaut Molinié, Nina Obad, Céline Léon, Giorgio Seano, Hrvoje Miletic, Dieter Henrik Heiland, Giovanni Marsicano, Macha Nikolski, Rolf Bjerkvig, Andreas Bikfalvi, Thomas Daubon
EMBO Mol Med. 2022-10-24
10.15252/emmm.202115343

Inhibition of the sodium-dependent HCO3- transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype.
Vinciane Saint-Criq, Anita Guequén, Amber R Philp, Sandra Villanueva, Tábata Apablaza, Ignacio Fernández-Moncada, Agustín Mansilla, Livia Delpiano, Iván Ruminot, Cristian Carrasco, Michael A Gray, Carlos A Flores
eLife. 2022-05-30
10.7554/elife.75871

CB1R-dependent regulation of astrocyte physiology and astrocyte-neuron interactions
Ana Covelo, Abel Eraso-Pichot, Ignacio Fernández-Moncada, Román Serrat, Giovanni Marsicano
Neuropharmacology. 2021-06-01
10.1016/j.neuropharm.2021.108678

Subcellular specificity of cannabinoid effects in striatonigral circuits.
Soria-Gomez E, Pagano Zottola AC, Mariani Y, Desprez T, Barresi M, Bonilla-Del Río I, Muguruza C, Le Bon-Jego M, Julio-Kalajzić F, Flynn R, Terral G, Fernández-Moncada I, Robin LM, Oliveira da Cruz JF, Corinti S, Amer YO, Goncalves J, Varilh M, Cannich A, Redon B, Zhao Z, Lesté-Lasserre T, Vincent P, Tolentino-Cortes T, Busquets-García A, Puente N, Bains JS, Hebert-Chatelain E, Barreda-Gómez G, Chaouloff F, Lohman AW, Callado LF, Grandes P, Baufreton J, Marsicano G, Bellocchio L.
Neuron. 2021-03-01
10.1016/j.neuron.2021.03.007

Bidirectional astrocytic GLUT1 activation by elevated extracellular K+
Ignacio Fernández‐Moncada, Daniel Robles‐Maldonado, Pablo Castro, Karin Alegría, Robert Epp, Iván Ruminot, Luis Felipe Barros
Glia. 2020-12-05
10.1002/glia.23944

Aerobic Glycolysis in the Brain: Warburg and Crabtree Contra Pasteur
L. Felipe Barros, Iván Ruminot, Alejandro San Martín, Rodrigo Lerchundi, Ignacio Fernández-Moncada, Felipe Baeza-Lehnert
Neurochem Res. 2020-01-24
10.1007/s11064-020-02964-w

Neuronal control of astrocytic respiration through a variant of the Crabtree effect
Ignacio Fernández-Moncada, Iván Ruminot, Daniel Robles-Maldonado, Karin Alegría, Joachim W. Deitmer, L. Felipe Barros
Proc Natl Acad Sci USA. 2018-01-29
10.1073/pnas.1716469115

Near-critical GLUT1 and Neurodegeneration
L. Felipe Barros, Alejandro San Martín, Ivan Ruminot, Pamela Y. Sandoval, Ignacio Fernández-Moncada, Felipe Baeza-Lehnert, Robinson Arce-Molina, Yasna Contreras-Baeza, Francisca Cortés-Molina, Alex Galaz, Karin Alegría
Journal of Neuroscience Research. 2017-02-02
10.1002/jnr.23998

Targeting of astrocytic glucose metabolism by beta-hydroxybutyrate
Rocío Valdebenito, Iván Ruminot, Pamela Garrido-Gerter, Ignacio Fernández-Moncada, Linda Forero-Quintero, Karin Alegría, Holger M Becker, Joachim W Deitmer, L Felipe Barros
J Cereb Blood Flow Metab. 2016-07-22
10.1177/0271678X15613955

NH4+ triggers the release of astrocytic lactate via mitochondrial pyruvate shunting
Rodrigo Lerchundi, Ignacio Fernández-Moncada, Yasna Contreras-Baeza, Tamara Sotelo-Hitschfeld, Philipp Mächler, Matthias T. Wyss, Jillian Stobart, Felipe Baeza-Lehnert, Karin Alegría, Bruno Weber, L. Felipe Barros
Proc Natl Acad Sci USA. 2015-08-18
10.1073/pnas.1508259112

Channel-mediated lactate release by K+ stimulated astrocytes
T. Sotelo-Hitschfeld, M. I. Niemeyer, P. Machler, I. Ruminot, R. Lerchundi, M. T. Wyss, J. Stobart, I. Fernandez-Moncada, R. Valdebenito, P. Garrido-Gerter, Y. Contreras-Baeza, B. L. Schneider, P. Aebischer, S. Lengacher, A. San Martin, J. Le Douce, G. Bonvento, P. J. Magistretti, F. V. Sepulveda, B. Weber, L. F. Barros
Journal of Neuroscience. 2015-03-11
10.1523/JNEUROSCI.5036-14.2015

Single-cell imaging tools for brain energy metabolism: a review
Alejandro San Martín, Tamara Sotelo-Hitschfeld, Rodrigo Lerchundi, Ignacio Fernández-Moncada, Sebastian Ceballo, Rocío Valdebenito, Felipe Baeza-Lehnert, Karin Alegría, Yasna Contreras-Baeza, Pamela Garrido-Gerter, Ignacio Romero-Gómez, L. Felipe Barros
Neurophoton. 2014-06-12
10.1117/1.nph.1.1.011004

Non-preferential fuelling of the Na+/K+-ATPase pump
Ignacio Fernández-Moncada, L. Felipe Barros
Biochemical Journal. 2014-05-29
10.1042/bj20140003

Small is fast: Astrocytic glucose and lactate metabolism at cellular resolution
L. F. Barros, A. San Martín, T. Sotelo-Hitschfeld, R. Lerchundi, I. Fernández-Moncada, I. Ruminot, R. Gutiérrez, R. Valdebenito, S. Ceballo, K. Alegría, F. Baeza-Lehnert, D. Espinoza
Front. Cell. Neurosci.. 2013-01-01
10.3389/fncel.2013.00027

Acute feedback control of astrocytic glycolysis by lactate
T. Sotelo-Hitschfeld, I. FernáNdez-Moncada, L. F. Barros
Glia. 2012-01-30
10.1002/glia.22304