Remission from addiction: erasing the wrong circuits or making new ones?
Michel Engeln, Serge H. Ahmed
Nat. Rev. Neurosci.. 2024-12-11
10.1038/s41583-024-00886-y

The multiple faces of footshock punishment in animal research on addiction
Michel Engeln, Serge H. Ahmed
Neurobiology of Learning and Memory. 2024-06-01
10.1016/j.nlm.2024.107955

Bidirectional relationship between attentional deficits and escalation of nicotine intake in male rats
Caroline Vouillac-Mendoza, Serge H. Ahmed, Karine Guillem
Psychopharmacology. 2024-05-14
10.1007/s00213-024-06604-x

Knowledge by omission: the significance of omissions in the 5-choice serial reaction time task
Caroline Vouillac-Mendoza, Audrey Durand, Serge H. Ahmed, Karine Guillem
Psychopharmacology. 2024-03-06
10.1007/s00213-024-06564-2

The importance of choice and agency in animal models of addiction
Serge H. Ahmed
J Neural Transm. 2023-10-31
10.1007/s00702-023-02712-8

Large‐scale brain correlates of sweet versus cocaine reward in rats
Magalie Lenoir, Sylvia Navailles, Youna Vandaele, Caroline Vouillac‐Mendoza, Karine Guillem, Serge H. Ahmed
Eur J of Neuroscience. 2022-12-01
10.1111/ejn.15879

Cocaine falls into oblivion during volitional initiation of choice trials
Youna Vandaele, Eric Augier, Caroline Vouillac‐Mendoza, Serge H. Ahmed
Addiction Biology. 2022-10-04
10.1111/adb.13235

Altered neuronal activity in the ventromedial prefrontal cortex drives nicotine intake escalation
Myriam Abarkan, Giulia R. Fois, Caroline Vouillac-Mendoza, Serge H. Ahmed, Karine Guillem
Neuropsychopharmacol.. 2022-08-30
10.1038/s41386-022-01428-9

Large-scale brain correlates of sweet versus cocaine reward in rats
Magalie Lenoir, Sylvia Navailles, Youna Vandaele, Caroline Vouillac-Mendoza, Karine Guillem, Serge H. Ahmed
Preprint bioRxiv. 2022-06-02
10.1101/2022.06.01.494287

Inhibition of striatal SEZ6 by miR-3594-5p is a drug-specific marker for late-stage heroin intake escalation
Magalie Lenoir, Isabella Bondi, Loïc Clemenceau, Isabelle Nondier, Margaux Ballé, Sébastien Jacques, Angéline Duché, Corinne Canestrelli, Séverine Martin-Lannerée, Sophie Mouillet-Richard, Jenny M. Gunnersen, Serge H. Ahmed, Nicolas Marie, Florence Noble
. 2021-07-26
10.1101/2021.07.26.453355

Probing the decision-making mechanisms underlying choice between drug and nondrug rewards in rats
Youna Vandaele, Magalie Lenoir, Caroline Vouillac-Mendoza, Karine Guillem, Serge H Ahmed
eLife. 2021-04-26
10.7554/eLife.64993

Habit, choice and addiction
Y. Vandaele, S. H. Ahmed
Neuropsychopharmacol.. 2020-11-09
10.1038/s41386-020-00899-y

Loss of resistance to punishment of cocaine use after prior experience
Audrey Durand, Paul Girardeau, Luana Freese, Serge H. Ahmed
Preprint bioRxiv. 2020-07-26
10.1101/2020.07.24.219170

Animal Models of the Behavioral Symptoms of Substance Use Disorders
Louk J.M.J. Vanderschuren, Serge H. Ahmed
Cold Spring Harb Perspect Med. 2020-06-08
10.1101/cshperspect.a040287

Habitual Preference for the Nondrug Reward in a Drug Choice Setting
Youna Vandaele, Karine Guillem, Serge H. Ahmed
Front. Behav. Neurosci.. 2020-05-25
10.3389/fnbeh.2020.00078

Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction
Ludivine Canchy, Paul Girardeau, Audrey Durand, Caroline Vouillac-Mendoza, Serge H. Ahmed
Neuropsychopharmacology. 2021-01
10.1038/s41386-020-0786-9

Reorganization of Theta Phase-Locking in the Orbitofrontal Cortex Drives Cocaine Choice Under the Influence
Karine Guillem, Serge H Ahmed
Sci Rep. 2020-05-15
10.1038/s41598-020-64962-w

Sugar intake and craving during alcohol withdrawal in alcohol use disorder inpatients
Régis Alarcon, Margaux Tiberghien, Raphael Trouillet, Stéphanie Pelletier, Amandine Luquiens, Serge H. Ahmed, Bertrand Nalpas, Stéphanie Alaux‐Cantin, Mickaël Naassila, Pascal Perney
Addiction Biology. 2020-04-19
10.1111/adb.12907

Relapse to cocaine use persists following extinction of drug-primed craving
Paul Girardeau, Sylvia Navailles, Audrey Durand, Caroline Vouillac-Mendoza, Karine Guillem, Serge H. Ahmed
Neuropharmacology. 2019-06-01
10.1016/j.neuropharm.2019.05.036

A neuronal population code for resemblance between drug and nondrug reward outcomes in the orbitofrontal cortex
Karine Guillem, Serge H. Ahmed
Brain Struct Funct. 2018-12-11
10.1007/s00429-018-1809-8

Trying to make sense of rodents' drug choice behavior
Serge H. Ahmed
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2018-12-01
10.1016/j.pnpbp.2017.09.027

A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study
Murat Yücel, Erin Oldenhof, Serge H. Ahmed, David Belin, Joel Billieux, Henrietta Bowden-Jones, Adrian Carter, Samuel R. Chamberlain, Luke Clark, Jason Connor, Mark Daglish, Geert Dom, Pinhas Dannon, Theodora Duka, Maria Jose Fernandez-Serrano, Matt Field, Ingmar Franken, Rita Z. Goldstein, Raul Gonzalez, Anna E. Goudriaan, Jon E. Grant, Matthew J. Gullo, Robert Hester, David C. Hodgins, Bernard Le Foll, Rico S. C. Lee, Anne Lingford-Hughes, Valentina Lorenzetti, Scott J. Moeller, Marcus R. Munafò, Brian Odlaug, Marc N. Potenza, Rebecca Segrave, Zsuzsika Sjoerds, Nadia Solowij, Wim van den Brink, Ruth J. van Holst, Valerie Voon, Reinout Wiers, Leonardo F. Fontenelle, Antonio Verdejo-Garcia
Addiction. 2018-10-05
10.1111/add.14424

Individual decision-making in the causal pathway to addiction: contributions and limitations of rodent models.
Serge H. Ahmed
Pharmacology Biochemistry and Behavior. 2018-01-01
10.1016/j.pbb.2017.07.005

Misdeed of the need: towards computational accounts of transition to addiction.
Mehdi Keramati, Serge H Ahmed, Boris S Gutkin
Current Opinion in Neurobiology. 2017-10-01
10.1016/j.conb.2017.08.014

Incubation of Accumbal Neuronal Reactivity to Cocaine Cues During Abstinence Predicts Individual Vulnerability to Relapse.
Karine Guillem, Serge H Ahmed
Neuropsychopharmacology. 2017-09-18
10.1038/npp.2017.224

Neuronal representation of individual heroin choices in the orbitofrontal cortex
Karine Guillem, Viridiana Brenot, Audrey Durand, Serge H. Ahmed
Addiction Biology. 2017-07-13
10.1111/adb.12536

Preference for Cocaine is Represented in the Orbitofrontal Cortex by an Increased Proportion of Cocaine Use-Coding Neurons.
Karine Guillem, Serge H. Ahmed
Cereb. Cortex. 2017-01-04
10.1093/cercor/bhw398

Cocaine addiction as a homeostatic reinforcement learning disorder.
Mehdi Keramati, Audrey Durand, Paul Girardeau, Boris Gutkin, Serge H. Ahmed
Psychological Review. 2017-01-01
10.1037/rev0000046

Erratum to: Review of the nutritional benefits and risks related to intense sweeteners.
Olivier Bruyère, Serge H. Ahmed, Catherine Atlan, Jacques Belegaud, Murielle Bortolotti, Marie-Chantal Canivenc-Lavier, Sybil Charrière, Jean-Philippe Girardet, Sabine Houdart, Esther Kalonji, Perrine Nadaud, Fabienne Rajas, Gérard Slama, Irène Margaritis
Arch Public Health. 2015-10-23
10.1186/s13690-015-0102-z

Review of the nutritional benefits and risks related to intense sweeteners.
Olivier Bruyère, Serge H. Ahmed, Catherine Atlan, Jacques Belegaud, Murielle Bortolotti, Marie-Chantal Canivenc-Lavier, Sybil Charrière, Jean-Philippe Girardet, Sabine Houdart, Esther Kalonji, Perrine Nadaud, Fabienne Rajas, Gérard Slama, Irène Margaritis
Arch Public Health. 2015-10-01
10.1186/s13690-015-0092-x

Rats quit nicotine for a sweet reward following an extensive history of nicotine use.
Carmen Huynh, Justine Fam, Serge H. Ahmed, Kelly J. Clemens
Addiction Biology. 2015-09-16
10.1111/adb.12306

Choosing under the influence: A drug-specific mechanism by which the setting controls drug choices in rats
Youna Vandaele, Lauriane Cantin, Fuschia Serre, Caroline Vouillac-Mendoza, Serge H Ahmed
Neuropsychopharmacol. 2015-07-01
10.1038/npp.2015.195

Alternative models of addiction.
Hanna Pickard, Serge H. Ahmed, Bennett Foddy
Front. Psychiatry. 2015-02-13
10.3389/fpsyt.2015.00020

Escalation of cocaine intake and incubation of cocaine seeking are correlated with dissociable neuronal processes in different accumbens subregions.
Karine Guillem, Serge H. Ahmed, Laura L. Peoples
Biological Psychiatry. 2014-07-01
10.1016/j.biopsych.2013.08.032

Coordinated Recruitment of Cortical-Subcortical Circuits and Ascending Dopamine and Serotonin Neurons During Inhibitory Control of Cocaine Seeking in Rats.
Sylvia Navailles, Karine Guillem, Caroline Vouillac-Mendoza, Serge H. Ahmed
Cereb. Cortex. 2014-05-28
10.1093/cercor/bhu112

A redescription of data does not count as a general theory.
Serge H. Ahmed
Psychopharmacology. 2014-05-27
10.1007/s00213-014-3622-2

Drug versus sweet reward: greater attraction to and preference for sweet versus drug cues.
Heather B. Madsen, Serge H. Ahmed
Addiction Biology. 2014-03-07
10.1111/adb.12134

Neurobiology of addiction versus drug use driven by lack of choice.
Serge H Ahmed, Magalie Lenoir, Karine Guillem
Current Opinion in Neurobiology. 2013-08-01
10.1016/j.conb.2013.01.028

Levodopa gains psychostimulant-like properties after nigral dopaminergic loss.
Michel Engeln, Stefania Fasano, Serge H. Ahmed, Martine Cador, Veerle Baekelandt, Erwan Bezard, Pierre-Olivier Fernagut
Ann Neurol.. 2013-07-01
10.1002/ana.23881

Sugar addiction: pushing the drug-sugar analogy to the limit.
Serge H. Ahmed, Karine Guillem, Youna Vandaele
Current Opinion in Clinical Nutrition and Metabolic Care. 2013-07-01
10.1097/mco.0b013e328361c8b8

A choice-based screening method for compulsive drug users in rats.
Magalie Lenoir, Eric Augier, Caroline Vouillac, Serge H. Ahmed
Current Protocols in Neuroscience. 2013-07-01
10.1002/0471142301.ns0944s64

Discriminative inhibitory control of cocaine seeking involves the prelimbic prefrontal cortex.
Claudia Mihindou, Karine Guillem, Sylvia Navailles, Caroline Vouillac, Serge H. Ahmed
Biological Psychiatry. 2013-02-01
10.1016/j.biopsych.2012.08.011

Extended heroin access increases heroin choices over a potent nondrug alternative
Magalie Lenoir, Lauriane Cantin, Nathalie Vanhille, Fuschia Serre, Serge H Ahmed
Neuropsychopharmacol. 2013-01-15
10.1038/npp.2013.17

Reinforcing properties of Pramipexole in normal and parkinsonian rats.
Michel Engeln, Serge H. Ahmed, Caroline Vouillac, François Tison, Erwan Bezard, Pierre-Olivier Fernagut
Neurobiology of Disease. 2013-01-01
10.1016/j.nbd.2012.08.005

Animal studies of addictive behavior.
L. J. M. J. Vanderschuren, S. H. Ahmed
Cold Spring Harbor Perspectives in Medicine. 2012-12-18
10.1101/cshperspect.a011932

The science of making drug-addicted animals.
S.H. Ahmed
Neuroscience. 2012-06-01
10.1016/j.neuroscience.2011.08.014

Sugars, addiction and obesity
S. H. Ahmed
Obes. 2012-02-03
10.1007/s11690-012-0307-z

Toward an evolutionary basis for resilience to drug addiction.
Serge H. Ahmed
Behav Brain Sci. 2011-11-10
10.1017/s0140525x11000677

Drug specificity in extended access cocaine and heroin self-administration.
Magalie Lenoir, Karyn Guillem, George F. Koob, Serge H. Ahmed
Addiction Biology. 2011-10-13
10.1111/j.1369-1600.2011.00385.x

Diazepam promotes choice of abstinence in cocaine self-administering rats.
Eric Augier, Caroline Vouillac, Serge H. Ahmed
Addiction Biology. 2011-09-28
10.1111/j.1369-1600.2011.00368.x

Preclinical validation of a novel cocaine exposure therapy for relapse prevention.
Claudia Mihindou, Caroline Vouillac, George F. Koob, Serge H. Ahmed
Biological Psychiatry. 2011-09-01
10.1016/j.biopsych.2011.03.036

Cracking the molecular code of cocaine addiction.
S. H. Ahmed, P. J. Kenny
ILAR Journal. 2011-01-01
10.1093/ilar.52.3.309

Validation crisis in animal models of drug addiction: beyond non-disordered drug use toward drug addiction.
Serge H. Ahmed
Neuroscience & Biobehavioral Reviews. 2010-11-01
10.1016/j.neubiorev.2010.04.005

Cocaine is low on the value ladder of rats: Possible evidence for resilience to addiction
Lauriane Cantin, Magalie Lenoir, Eric Augier, Nathalie Vanhille, Sarah Dubreucq, Fuschia Serre, Caroline Vouillac, Serge H. Ahmed
PLoS ONE. 2010-07-28
10.1371/journal.pone.0011592

Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats.
Leandro F. Vendruscolo, Aliou B. Gueye, Muriel Darnaudéry, Serge H. Ahmed, Martine Cador
PLoS ONE. 2010-02-19
10.1371/journal.pone.0009296

Risk-prone individuals prefer the wrong options on a rat version of the Iowa Gambling Task.
Marion Rivalan, Serge H. Ahmed, Françoise Dellu-Hagedorn
Biological Psychiatry. 2009-10-01
10.1016/j.biopsych.2009.04.008

Computational approaches to the neurobiology of drug addiction.
S. H. Ahmed, M. Graupner, B. Gutkin
Pharmacopsychiatry. 2009-05-01
10.1055/s-0029-1216345

Supply of a nondrug substitute reduces escalated heroin consumption.
Magalie Lenoir, Serge H Ahmed
Neuropsychopharmacol. 2007-10-31
10.1038/sj.npp.1301602

The simulation of addiction: pharmacological and neurocomputational models of drug self-administration.
Ahmed SH, Bobashev G, Gutkin BS.
Drug and Alcohol Dependence. 2007-10-01
10.1016/j.drugalcdep.2007.01.008

Intense sweetness surpasses cocaine reward
Magalie Lenoir, Fuschia Serre, Lauriane Cantin, Serge H. Ahmed
PLoS ONE. 2007-08-01
10.1371/journal.pone.0000698

A critical transition in cocaine self-administration: behavioral and neurobiological implications.
Amandine Zittel-Lazarini, Martine Cador, Serge H. Ahmed
Psychopharmacology. 2007-02-21
10.1007/s00213-007-0724-0

Explaining the escalation of drug use in substance dependence: models and appropriate animal laboratory tests.
Gerald Zernig, Serge H. Ahmed, Rudolf N. Cardinal, Drake Morgan, Elio Acquas, Richard W. Foltin, Paul Vezina, S. Stevens Negus, Jose A. Crespo, Petra Stöckl, Petra Grubinger, Ekkehard Madlung, Christian Haring, Martin Kurz, Alois Saria
Pharmacology. 2007-01-01
10.1159/000103923

Heroin-induced reinstatement is specific to compulsive heroin use and dissociable from heroin reward and sensitization.
Magalie Lenoir, Serge H Ahmed
Neuropsychopharmacol. 2006-04-26
10.1038/sj.npp.1301083

Imbalance between drug and non-drug reward availability: a major risk factor for addiction.
Serge H. Ahmed
European Journal of Pharmacology. 2005-12-01
10.1016/j.ejphar.2005.09.036

Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction.
S. H. Ahmed, R. Lutjens, L. D. van der Stap, D. Lekic, V. Romano-Spica, M. Morales, G. F. Koob, V. Repunte-Canonigo, P. P. Sanna
Proceedings of the National Academy of Sciences. 2005-08-02
10.1073/pnas.0504438102

Dissociation of psychomotor sensitization from compulsive cocaine consumption.
Serge H Ahmed, Martine Cador
Neuropsychopharmacol. 2005-07-20
10.1038/sj.npp.1300834

Mesolimbic dopamine drives the diurnal variation in opiate-induced feeding.
M BARBANO, L STINUS, M CADOR, S AHMED
Pharmacology Biochemistry and Behavior. 2005-07-01
10.1016/j.pbb.2005.04.009

Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function.
Serge H. Ahmed, George F. Koob
Psychopharmacology. 2005-02-25
10.1007/s00213-005-2180-z

Neuroscience. Addiction as compulsive reward prediction.
S. H. Ahmed
Science. 2004-12-10
10.1126/science.1107071

Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens.
G. Martin
Journal of Pharmacology and Experimental Therapeutics. 2004-05-26
10.1124/jpet.104.067504

A non-invasive gating device for continuous drug delivery that allows control over the timing and duration of spontaneous opiate withdrawal.
M.R Azar, S.H Ahmed, R Lintz, T Gutierrez, L Stinus, G.F Koob
Journal of Neuroscience Methods. 2004-05-01
10.1016/j.jneumeth.2003.12.008

Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake.
Serge H. Ahmed, George F. Koob
Psychopharmacology. 2004-04-01
10.1007/s00213-003-1682-9

Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels.
Serge H. Ahmed, Daniel Lin, George F. Koob, Loren H. Parsons
Journal of Neurochemistry. 2004-02-04
10.1046/j.1471-4159.2003.01833.x

Neurobiological mechanisms in the transition from drug use to drug dependence.
George F Koob, Serge H Ahmed, Benjamin Boutrel, Scott A Chen, Paul J Kenny, Athina Markou, Laura E O'Dell, Loren H Parsons, Pietro Paolo Sanna
Neuroscience & Biobehavioral Reviews. 2004-01-01
10.1016/j.neubiorev.2003.11.007

The transition from controlled to compulsive drug use is associated with a loss of sensitization.
Osnat Ben-Shahar, Serge H. Ahmed, George F. Koob, Aaron Ettenberg
Brain Research. 2004-01-01
10.1016/j.brainres.2003.09.053

Conditioning and opiate withdrawal.
G. Schulteis, S. H. Ahmed, A. C. Morse, G. F. Koob, B. J. Everitt
Nature. 2000-06-01
10.1038/35016630

Persistent increase in the motivation to take heroin in rats with a history of drug escalation.
S Ahmed
Neuropsychopharmacology. 2000-04-01
10.1016/s0893-133x(99)00133-5

Microinjections of an opiate receptor antagonist into the bed nucleus of the stria terminalis suppress heroin self-administration in dependent rats.
John R. Walker, Serge H. Ahmed, K.Noelle Gracy, George F. Koob
Brain Research. 2000-01-01
10.1016/s0006-8993(99)02288-x

Long-lasting increase in the set point for cocaine self-administration after escalation in rats.
S. H. Ahmed, George F. Koob
Psychopharmacology. 1999-10-04
10.1007/s002130051121

Transition from moderate to excessive drug intake: change in hedonic set point.
S. H. Ahmed
Science. 1998-10-09
10.1126/science.282.5387.298

Corticotropin-releasing factor receptor blockade enhances conditioned aversive properties of cocaine in rats.
S. C. Heinrichs, Alwin Klaassen, George F. Koob, Gery Schulteis, Serge Ahmed, Errol B. De Souza
Psychopharmacology. 1998-03-23
10.1007/s002130050563

Amphetamine-induced conditioned activity is insensitive to perturbations known to affect pavlovian conditioned responses in rats.
Serge H. Ahmed, Luis Stinus, Martine Cador
Behavioral Neuroscience. 1998-01-01
10.1037//0735-7044.112.5.1167

Cocaine- but not food-seeking behavior is reinstated by stress after extinction.
S. H. Ahmed, George F. Koob
Psychopharmacology. 1997-08-05
10.1007/s002130050347

Amphetamine-induced conditioned activity does not result from a failure of rats to habituate to novelty.
S. H. Ahmed, P. Oberling, G. Sandner, G. Di Scala
Psychopharmacology. 1996-02-01
10.1007/bf02246642

Amphetamine-induced conditioned activity in rats: comparison with novelty-induced activity and role of the basolateral amygdala.
Serge H. Ahmed, Martine Cador, Michel Le Moal, Luis Stinus
Behavioral Neuroscience. 1995-01-01
10.1037//0735-7044.109.4.723

Social deprivation enhances the vulnerability of male Wistar rats to stressor- and amphetamine-induced behavioral sensitization.
S. H. Ahmed, L. Stinus, M. Le Moal, M. Cador
Psychopharmacology. 1995-01-01
10.1007/bf02245106

Corticotropin-releasing factor induces a place aversion independent of its neuroendocrine role.
M. Cador, S.H. Ahmed, G.F. Koob, M. Le Moal, L. Stinus
Brain Research. 1992-12-01
10.1016/0006-8993(92)91487-y