Saffron extract interferes with lipopolysaccharide-induced brain activation of the kynurenine pathway and impairment of monoamine neurotransmission in mice
Camille Monchaux de Oliveira, Jennifer Morael, Alexandrine Guille, Camille Amadieu, Sylvie Vancassel, David Gaudout, Lucile Capuron, Line Pourtau, Nathalie Castanon
Front. Nutr.. 2023-10-05
10.3389/fnut.2023.1267839

Acute Effect of a Saffron Extract (Safr’InsideTM) and Its Main Volatile Compound on the Stress Response in Healthy Young Men: A Randomized, Double Blind, Placebo-Controlled, Crossover Study
Camille Pouchieu, Line Pourtau, Julie Brossaud, David Gaudout, Jean-Benoit Corcuff, Lucile Capuron, Nathalie Castanon, Pierre Philip
Nutrients. 2023-06-27
10.3390/nu15132921

Tetrahydrobiopterin modulates the behavioral neuroinflammatory response to an LPS challenge in mice
S. Vancassel, H. Fanet, N. Castanon, C. Monchaux De Oliveira, S. Cussotto, L. Capuron
Brain, Behavior, and Immunity. 2022-10-01
10.1016/j.bbi.2022.06.016

Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (SafrInsideTM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders
Fabien Wauquier, Line Boutin-Wittrant, Line Pourtau, David Gaudout, Benjamin Moras, Adeline Vignault, Camille Monchaux De Oliveira, Julien Gabaston, Carole Vaysse, Karène Bertrand, Hélène Abrous, Lucile Capuron, Nathalie Castanon, David Vauzour, Véronique Roux, Nicolas Macian, Gisèle Pickering, Yohann Wittrant
Nutrients. 2022-04-05
10.3390/nu14071511

Prevention of Stress-Induced Depressive-like Behavior by Saffron Extract Is Associated with Modulation of Kynurenine Pathway and Monoamine Neurotransmission
Camille Monchaux De Oliveira, Véronique De Smedt-Peyrusse, Jennifer Morael, Sylvie Vancassel, Lucile Capuron, David Gaudout, Line Pourtau, Nathalie Castanon
Pharmaceutics. 2021-12-14
10.3390/pharmaceutics13122155

A new experimental design to study inflammation-related versus non-inflammation-related depression in mice
Pierre Cardinal, Camille Monchaux de Oliveira, Julie Sauvant, Aline Foury, Muriel Darnaudéry, Sylvie Vancassel, Nathalie Castanon, Lucile Capuron
J Neuroinflammation. 2021-12-01
10.1186/s12974-021-02330-9

Anthocyanin-rich bilberry extract exerts a complex nutrigenomic effect in hippocampus of ApoE-/- mice
Irena Krga, Anne-Laure Dinel, Sophie Laye, Nathalie Castanon, Dragan Milenkovic
Free Radical Biology and Medicine. 2021-12-01
10.1016/j.freeradbiomed.2021.08.117

Nutrigenomic modification induced by anthocyanin-rich bilberry extract in the hippocampus of ApoE-/- mice
Dragan Milenkovic, Irena Krga, Anne-Laure Dinel, Christine Morand, Sophie Laye, Nathalie Castanon
Journal of Functional Foods. 2021-10-01
10.1016/j.jff.2021.104609

Tetrahydrobioterin (BH4) Pathway: From Metabolism to Neuropsychiatry
H. Fanet, L. Capuron, N. Castanon, F. Calon, S. Vancassel
CN. 2021-04-29
10.2174/1570159x18666200729103529

Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission
Camille Monchaux De Oliveira, Line Pourtau, Sylvie Vancassel, Camille Pouchieu, Lucile Capuron, David Gaudout, Nathalie Castanon
Nutrients. 2021-03-11
10.3390/nu13030904

Inflammatory Bases of Neuropsychiatric Symptom Domains: Mechanisms and Specificity.
Bruno Aouizerate, Sylvie Vancassel, Nathalie Castanon, Lucile Capuron
Immuno-Psychiatry. 2021-01-01
10.1007/978-3-030-71229-7_20

The gut microbiota metabolite indole increases emotional responses and adrenal medulla activity in chronically stressed male mice
Hayatte-Dounia Mir, Alexandre Milman, Magali Monnoye, Véronique Douard, Catherine Philippe, Agnès Aubert, Nathalie Castanon, Sylvie Vancassel, Nathalie C. Guérineau, Laurent Naudon, Sylvie Rabot
Psychoneuroendocrinology. 2020-09-01
10.1016/j.psyneuen.2020.104750

Rapeseed oil fortified with micronutrients improves cognitive alterations associated with metabolic syndrome
Célia Fourrier, Camille Kropp, Agnès Aubert, Julie Sauvant, Carole Vaysse, Jean-Michel Chardigny, Sophie Layé, Corinne Joffre, Nathalie Castanon
Brain, Behavior, and Immunity. 2019-11-01
10.1016/j.bbi.2019.11.002

Obesity and Depression: Shared Pathophysiology and Translational Implications
Lison Huet, Ines Delgado, Bruno Aouizerate, Nathalie Castanon, Lucile Capuron
Neurobiology of Depression. 2019-01-01
10.1016/b978-0-12-813333-0.00016-0

Brain tumor necrosis factor-α mediates anxiety-like behavior in a mouse model of severe obesity.
Célia Fourrier, Clémentine Bosch-Bouju, Raphaël Boursereau, Julie Sauvant, Agnès Aubert, Lucile Capuron, Guillaume Ferreira, Sophie Layé, Nathalie Castanon
Brain, Behavior, and Immunity. 2018-11-01
10.1016/j.bbi.2018.11.316

Role of Inflammation in Neuropsychiatric Comorbidity of Obesity: Experimental and Clinical Evidence
Célia Fourrier, Lucile Capuron, Nathalie Castanon
Inflammation and Immunity in Depression. 2018-01-01
10.1016/b978-0-12-811073-7.00020-9

Switching adolescent high-fat diet to adult control diet restores neurocognitive alterations
Chloé Boitard, Shauna L. Parkes, Amandine Cavaroc, Frédéric Tantot, Nathalie Castanon, Sophie Layé, Sophie Tronel, Gustavo Pacheco-Lopez, Etienne Coutureau, Guillaume Ferreira
Front. Behav. Neurosci.. 2016-11-21
10.3389/fnbeh.2016.00225

Obesity- and Neuroinflammation-Associated Mood and Cognitive Disorders
Nathalie Castanon, Giamal Luheshi, Sophie Layé
Neuroinflammation. 2015-03-06
10.1002/9781118732748.ch9

Animal Models to Study the Role of Kynurenine Pathway in Mood, Behavior, and Cognition
Nathalie Castanon
Targeting the Broadly Pathogenic Kynurenine Pathway. 2015-01-01
10.1007/978-3-319-11870-3_25

Cytokines and depression: experimental evidence and intermediate mechanisms
Robert Dantzer, Jason C. O’Connor, Nathalie Castanon, Jacques Lestage, Keith W. Kelley
Understanding depression. 2009-07-01
10.1093/med/9780199533077.003.0010

Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin
J. C. O'Connor, C. Andre, Y. Wang, M. A. Lawson, S. S. Szegedi, J. Lestage, N. Castanon, K. W. Kelley, R. Dantzer
Journal of Neuroscience. 2009-04-01
10.1523/JNEUROSCI.5032-08.2009

Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behavior
Jason C. O'Connor, Marcus A. Lawson, Caroline André, Eileen M. Briley, Sandra S. Szegedi, Jacques Lestage, Nathalie Castanon, Miles Herkenham, Robert Dantzer, Keith W. Kelley
J Immunol. 2009-02-20
10.4049/jimmunol.0802722

Inflammation, sickness behaviour and depression
Robert Dantzer, Nathalie Castanon, Jacques Lestage, Maite Moreau, Lucile Capuron
Depression and Physical Illness.
10.1017/cbo9780511544293.013

Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior
Maïté Moreau, Caroline André, Jason C. O’Connor, Sara A. Dumich, Jeffrey A. Woods, Keith W. Kelley, Robert Dantzer, Jacques Lestage, Nathalie Castanon
Brain, Behavior, and Immunity. 2008-10-01
10.1016/j.bbi.2008.04.001

Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration
Caroline André, Jason C. O'Connor, Keith W. Kelley, Jacques Lestage, Robert Dantzer, Nathalie Castanon
Journal of Neuroimmunology. 2008-08-01
10.1016/j.jneuroim.2008.06.011

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice
J C O'Connor, M A Lawson, C André, M Moreau, J Lestage, N Castanon, K W Kelley, R Dantzer
Mol Psychiatry. 2008-01-15
10.1038/sj.mp.4002148

Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system
Jonathan P Godbout, Maïté Moreau, Jacques Lestage, Jing Chen, Nathan L Sparkman, Jason O' Connor, Nathalie Castanon, Keith W Kelley, Robert Dantzer, Rodney W Johnson
Neuropsychopharmacol. 2007-12-12
10.1038/sj.npp.1301649

Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior
François Frenois, Maïté Moreau, Jason O’Connor, Marc Lawson, Charlotte Micon, Jacques Lestage, Keith W. Kelley, Robert Dantzer, Nathalie Castanon
Psychoneuroendocrinology. 2007-06-01
10.1016/j.psyneuen.2007.03.005

Bacille Calmette-Guérin inoculation induces chronic activation of peripheral and brain indoleamine 2,3-dioxygenase in mice
Maïté Moreau, Jacques Lestage, Danièle Verrier, Cécile Mormède, Keith W. Kelley, Robert Dantzer, Nathalie Castanon
J INFECT DIS. 2005-08-01
10.1086/431603

Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats
Nathalie Castanon, Chantal Médina, Cécile Mormède, Robert Dantzer
Psychoneuroendocrinology. 2004-07-01
10.1016/s0306-4530(03)00142-2

Conditioned taste aversion with lipopolysaccharide and peptidoglycan does not activate cytokine gene expression in the spleen and hypothalamus of mice
Cécile Mormède, Karine Palin, Keith W Kelley, Nathalie Castanon, Robert Dantzer
Brain, Behavior, and Immunity. 2004-03-01
10.1016/s0889-1591(03)00133-8

Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice
Alena Lira, Mingming Zhou, Nathalie Castanon, Mark S Ansorge, Joshua A Gordon, Jasmine H Francis, Maria Bradley-Moore, Josko Lira, Mark D Underwood, Victoria Arango, Hank F Kung, Myron A Hofer, René Hen, Jay A Gingrich
Biological Psychiatry. 2003-11-01
10.1016/s0006-3223(03)00696-6

Conditioned place aversion with interleukin-1beta in mice is not associated with activation of the cytokine network
Cécile Mormède, Nathalie Castanon, Chantal Médina, Robert Dantzer
Brain, Behavior, and Immunity. 2003-04-01
10.1016/s0889-1591(02)00054-5

Effects of antidepressants on cytokine production and actions
N CASTANON, B LEONARD, P NEVEU, R YIRMIYA
Brain, Behavior, and Immunity. 2002-10-01
10.1016/s0889-1591(02)00008-9

Chronic mild stress in mice decreases peripheral cytokine and increases central cytokine expression independently of IL-10 regulation of the cytokine network
Cécile Mormède, Nathalie Castanon, Chantal Médina, Elisabeth Moze, Jacques Lestage, Pierre J. Neveu, Robert Dantzer
Neuroimmunomodulation. 2002-01-01
10.1159/000071477

Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1beta in the rat
Nathalie Castanon, Rose-Marie Bluthé, Robert Dantzer
Psychopharmacology. 2001-02-22
10.1007/s002130000595

Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists
Nathalie Castanon, Kimberly Scearce-Levie, Jose J Lucas, Beatriz Rocha, René Hen
Pharmacology Biochemistry and Behavior. 2000-11-01
10.1016/s0091-3057(00)00389-0

Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats
Rose-Marie Bluthé, Nathalie Castanon, Florence Pousset, Adrian Bristow, Chris Ball, Jacques Lestage, Bruno Michaud, Keith W Kelley, Robert Dantzer
Psychoneuroendocrinology. 1999-04-01
10.1016/s0306-4530(98)00077-8

Is there evidence for an effect of antidepressant drugs on immune function?
Pierre J. Neveu, Nathalie Castanon
Advances in Experimental Medicine and Biology. 1999-01-01
10.1007/978-0-585-37970-8_15

Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor
Beatriz A. Rocha, Kimberly Scearce-Levie, José J. Lucas, Noboru Hiroi, Nathalie Castanon, John C. Crabbe, Eric J. Nestler, René Hen
Nature. 1998-05-01
10.1038/30259

Regulation of [3H]5-HT release in raphe, frontal cortex and hippocampus of 5-HT1B knock-out mice
Graciela Piñeyro, Nathalie Castanon, René Hen, Pierre Blier
NeuroReport. 1995-12-01
10.1097/00001756-199512290-00084

Genetic analysis of the relationships between behavioral and neuroendocrine traits in Roman High and Low Avoidance rat lines
Nathalie Castanon, Fernando Perez-Diaz, Pierre Mormède
Behav Genet. 1995-07-01
10.1007/bf02197288

Cocaine sensitivity in Roman High and Low Avoidance rats is modulated by sex and gonadal hormone status
Margaret Haney, Nathalie Castanon, Martine Cador, Michel Le Moal, Pierre Morme`de
Brain Research. 1994-05-01
10.1016/0006-8993(94)91651-9

Maturation of the behavioral and neuroendocrine differences between the Roman rat lines
Nathalie Castanon, Josette Dulluc, Michel Le Moal, Pierre Mormède
Physiology & Behavior. 1994-04-01
10.1016/0031-9384(94)90059-0

Psychobiogenetics: adapted tools for the study of the coupling between behavioral and neuroendocrine traits of emotional reactivity
N CASTANON, P MORMEDE
Psychoneuroendocrinology. 1994-01-01
10.1016/0306-4530(94)90065-5

Psychoneuroendocrine profile associated with hypertension or hyperactivity in spontaneously hypertensive rats
N. Castanon, E. D. Hendley, X. M. Fan, P. Mormede
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 1993-12-01
10.1152/ajpregu.1993.265.6.r1304

Prolactin as a link between behavioral and immune differences between the Roman rat lines
Nathalie Castanon, Josette Dulluc, Michel Le Moal, Pierre Mormède
Physiology & Behavior. 1992-06-01
10.1016/0031-9384(92)90314-r

Different responsiveness of spleen lymphocytes from two lines of psychogenetically selected rats (Roman high and low avoidance)
Carmen Sandi, Nathalie Castanon, Sergio Vitiello, Pierre J. Neveu, Pierre Morméde
Journal of Neuroimmunology. 1991-01-01
10.1016/0165-5728(91)90083-j

Multiple neuroendocrine responses to chronic social stress: interaction between individual characteristics and situational factors
Pierre Mormède, Valérie Lemaire, Nathalie Castanon, Josette Dulluc, Martine Laval, Michel Le Moal
Physiology & Behavior. 1990-06-01
10.1016/0031-9384(90)90358-b